The statistical analysis plan for the 0.9% Saline vs. Plasma-Lyte 148® for Intensive care fluid Therapy (SPLIT) study
نویسندگان
چکیده
1 Medical Research Institute of New Zealand, Wellington, New Zealand 2 Intensive Care Unit, Wellington Regional Hospital, Wellington, New Zealand 3 Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia 4 Department of Intensive Care Medicine, Christchurch Hospital, Christchurch, New Zealand 5 Department of Critical Care Medicine, Auckland City Hospital, Auckland, New Zealand 6 Intensive Care Unit, St George Hospital, Sydney, New South Wales, Australia 7 Critical Care Division, The George Institute for Global Health, Sydney, New South Wales, Australia 8 Cardiac and Vascular Intensive Care Unit, Auckland City Hospital, Auckland, New Zealand 9 Intensive Care Unit, Austin Hospital, Melbourne, VIC, Australia
منابع مشابه
Overview of the study protocols and statistical analysis plan for the Saline versus Plasma-Lyte 148 for Intravenous Fluid Therapy (SPLIT) research program.
BACKGROUND 0.9% saline is the most commonly used intravenous (IV) fluid in the world but recent data raise the possibility that, compared with buffered crystalloid fluids such as Plasma-Lyte 148, the administration of 0.9% saline might increase the risk of developing acute kidney injury. OBJECTIVE To provide an overview of the study protocols and statistical analysis plan for the six studies ...
متن کاملThe Plasma-Lyte 148 v Saline (PLUS) study protocol: a multicentre, randomised controlled trial of the effect of intensive care fluid therapy on mortality.
BACKGROUND 0.9% sodium chloride (saline) is the most commonly administered resuscitation fluid on a global basis but emerging evidence suggests that its high chloride content may have important adverse effects. OBJECTIVE To describe the study protocol for the Plasma- Lyte 148 v Saline study, which will test the hypothesis that in critically ill adult patients the use of Plasma-Lyte 148 (a buf...
متن کاملEffect of saline 0.9% or Plasma-Lyte 148 therapy on feeding intolerance in patients receiving nasogastric enteral nutrition.
OBJECTIVE To compare the effect of Plasma-Lyte (PL)-148 and saline 0.9% (saline) on gastrointestinal (GI) feeding intolerance in mechanically ventilated patients receiving nasogastric (NG) feeding in an intensive care unit. DESIGN AND SETTING A single-centre pilot study, nested within a multicentre, double-blind, cluster-randomised, double-crossover trial, performed in a mixed medical and sur...
متن کاملPlasma-Lyte 148: A clinical review
AIM To outline the physiochemical properties and specific clinical uses of Plasma-Lyte 148 as choice of solution for fluid intervention in critical illness, surgery and perioperative medicine. METHODS We performed an electronic literature search from Medline and PubMed (via Ovid), anesthesia and pharmacology textbooks, and online sources including studies that compared Plasma-Lyte 148 to othe...
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Background Kidney transplant recipients often receive large volumes of intravenous fluid replacement in the peri-operative period. Administration of 0.9% saline has previously been associated with acidosis, hyperkalaemia and acute kidney injury. The perioperative use of physiologically balanced replacement fluids may reduce the incidence of post-operative renal replacement therapy and hyperkala...
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